Moderate calorie restriction, as observed in the CALERIE trial, led to changes in gene expression in human muscle cells, suggesting improved muscle health. The study, led by Dr. Luigi Ferrucci, found over 1,000 genes expressed differently between calorie-restricted and non-calorie restricted participants, impacting pathways related to muscle formation, repair, and aging. These findings highlight the potential of moderate calorie restriction in preserving muscle function during aging.